Exocrine pancreatic insufficiency (EPI) occurs when the pancreas fails to produce enough digestive enzymes, particularly lipase, leading to poor digestion and absorption of nutrients, especially fats. EPI is commonly associated with such conditions as cystic fibrosis in children and various gastrointestinal disorders in adults. Symptoms typically include bloating, diarrhea, and weight loss due to fat malabsorption, which, if untreated, can lead to significant nutritional deficiencies.

Diagnosing EPI often involves recognizing these hallmark symptoms and conducting relevant tests to measure digestive enzyme activity. Treatment aims to restore normal digestive function, which significantly improves the patient's quality of life by reducing malnutrition and preventing long-term complications. Early intervention is important in managing the disease effectively because delayed treatment can lead to worsening symptoms and more severe health issues over time. EPI requires ongoing care and attention to ensure that patients maintain adequate nutrition and digestive health.