Packers cornerback Jaire Alexander practiced fully last week, but he will miss his fifth game with a posterior cruciate ligament injury in his knee.
Tom Pelissero of NFL Media reports that Alexander is "not himself," and the team will reevaluate Alexander's injury later this week.
Alexander has missed six of the past seven games, and he played only briefly in Week 11, seeing 10 snaps.
He has missed 18 of the Packers' past 32 games and 31 of the past 66.
The Packers' other inactives are linebacker Quay Walker (ankle), wide receiver Malik Heath, safety Javon Bullard (ankle), safety Evan Williams (quad) and offensive lineman Jacob Monk.
The Saints' inactives are quarterback Derek Carr (left hand), wide receiver Bub Means (ankle), running back Alvin Kamara (groin), wide receiver Marquez Valdes-Scantling (chest/illness), defensive tackle Nathan Shepherd (eye) and defensive tackle Khristian Boyd.